Certified Pediatric Hematology Oncology Nurse (CPHON) Practice Exam 2025 – Comprehensive All-in-One Resource for Exam Excellence!

The process described in relation to Warm Autoimmune Hemolytic Anemia (AIHA) involving IgG is accurately represented by the mechanism where IgG attaches to red blood cells (RBCs), which are then recognized and destroyed by the spleen. In this condition, the immune system produces antibodies, specifically IgG, that mistakenly bind to the patient's own RBCs. This binding marks the red blood cells as targets for destruction.

When the spleen recognizes these antibody-coated cells, it initiates phagocytosis, leading to the removal of these RBCs from circulation. The consequent hemolysis results in anemia, which is characterized by symptoms such as fatigue, pallor, and sometimes jaundice due to the breakdown of hemoglobin. This describes the underlying pathophysiology of Warm AIHA, where the immune response is misdirected against the individual’s own RBCs, causing their premature destruction.

The other options relate to different immune or physiological processes that do not specifically apply to the mechanisms of Warm AIHA. Thus, the correct answer captures the essence of how IgG plays a critical role in the destruction of red blood cells in this specific type of anemia.