Certified Pediatric Hematology Oncology Nurse (CPHON) Practice Exam 2026 – Comprehensive All-in-One Resource for Exam Excellence!

Hb Sc generally indicates a specific type of Sickle Cell Disease where the individual has one sickle hemoglobin gene (Hb S) and one normal hemoglobin gene (Hb C). This hemoglobin variant is typically associated with a milder form of the disease compared to Hb SS (sickle cell anemia). However, it can still cause significant manifestations of sickle cell crises, hemolytic anemia, and other complications.

Individuals with Hb Sc can experience symptoms ranging from mild to moderate severity. The condition often leads to fewer and less severe pain crises than those seen in Hb SS, but patients may still encounter complications, including splenic sequestration crises and increased risk for other health issues.

This understanding of Hb Sc as being associated with moderate to severe complications highlights the nuance in the severity spectrum of sickle cell disease, positioning it between mild and severe forms. Thus, the classification of Hb Sc as moderate to severe reflects the reality that while it may not be as severe as Hb SS cases, it is certainly more than just a benign carrier state or mild condition.